Article
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
Nature genetics - 1 Apr 2015
Andersson Anna K, Ma Jing, Wang Jianmin, Chen Xiang, Gedman Amanda Larson, Dang Jinjun, Nakitandwe Joy, Holmfeldt Linda, Parker Matthew, Easton John, Huether Robert, Kriwacki Richard, Rusch Michael, Wu Gang, Li Yongjin, Mulder Heather, Raimondi Susana, Pounds Stanley, Kang Guolian, Shi Lei, Becksfort Jared, Gupta Pankaj, Payne-Turner Debbie, Vadodaria Bhavin, Boggs Kristy, Yergeau Donald, Manne Jayanthi, Song Guangchun, Edmonson Michael, Nagahawatte Panduka, Wei Lei, Cheng Cheng, Pei Deqing, Sutton Rosemary, Venn Nicola C, Chetcuti Albert, Rush Amanda, Catchpoole Daniel, Heldrup Jesper, Fioretos Thoas, Lu Charles, Ding Li, Pui Ching-Hon, Shurtleff Sheila, Mullighan Charles G, Mardis Elaine R, Wilson Richard K, Gruber Tanja A, Zhang Jinghui, Downing James R
Abstract excerpt
Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis. To define its mutational landscape, we performed whole-genome, exome, RNA and targeted DNA sequencing on 65 infants (47 MLL-R and 18 non-MLL-R cases) and 20 older children (MLL-R cases) with leukemia. Our data show that infant MLL-R ALL has one of the lowest frequencies of somatic...
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