Article

Germline Variant Burden Warrants Universal Genetic Testing in Pediatric Myeloid Leukemia

2025-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Causal germline genetic variants are frequently detected in young (under age 40) patients presenting with myelodysplastic syndromes (MDS) or bone marrow failure (BMF), where progression to acute myeloid leukemia (AML) contributes substantially to mortality in these patients. We reasoned that de novo pediatric AML, which shares clinical and biological characteristics, might also share germline ge...

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Literature Corpus work: 4072c9a1-1f28-5253-948d-cf7292ed05fc
DOI: 10.1101/2025.07.29.25332166

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