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Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

22 Dec 2008

Abstract excerpt

Apolipoprotein (apo) E has roles beyond lipoprotein metabolism. The detrimental effects of apoE4 in cardiovascular, neurological, and infectious diseases correlate with its structural features (e.g., domain interaction) that distinguish it from apoE3 and apoE2. Structure/function studies revealed that apoE2 is severely defective in LDL receptor binding because of a structural difference that alters the receptor...

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PMID: 19106071
DOI: 10.1194/jlr.r800069-jlr200

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