Article

Within-Family GWAS does not Ameliorate the Decline in Prediction Accuracy across Populations

2024-12-13

Abstract excerpt

As polygenic prediction extends beyond the research domain to involve clinical applications, the urgency of solving the “portability problem” becomes amplified—that is, the fact that polygenic indices (PGI) constructed based on discovery analysis in one population (typically of exclusively continental European descent) predict poorly in other populations. In the present paper we test whether population differences...

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Literature Corpus work: c0a373e5-3fe6-5c1d-9e64-d9cdc661e469
DOI: 10.1101/2024.12.12.628188

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