Variable prediction accuracy of polygenic scores within an ancestry group.

Abstract excerpt

Fields as diverse as human genetics and sociology are increasingly using polygenic scores based on genome-wide association studies (GWAS) for phenotypic prediction. However, recent work has shown that polygenic scores have limited portability across groups of different genetic ancestries, restricting the contexts in which they can be used reliably and potentially creating serious inequities in future clinical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age Factors
• Share to Gene Frequency
• Share to Genetics, Population