Article

Within-family attenuation of polygenic risk score accuracy: Investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank

2025-09-02

Abstract excerpt

A central challenge in the field of polygenic risk prediction has been measuring and controlling for confounding effects mediated through population stratification. Traditionally, such control has been attempted through the inclusion of the top principal components (PCs) of variation and the use of linear mixed models in genome-wide association studies (GWAS). Reductions in test-statistic inflation, commonly asses...

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Literature Corpus work: afb5d697-e11e-5b38-b919-8813624bd46f
DOI: 10.1101/2025.08.28.25334633

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