Admixed Populations Improve Power for Variant Discovery and Portability in Genome-wide Association Studies

Abstract excerpt

Genome-wide association studies (GWAS) are primarily conducted in single-ancestry settings. The low transferability of results has limited our understanding of human genetic architecture across a range of complex traits. In contrast to homogeneous populations, admixed populations provide an opportunity to capture genetic architecture contributed from multiple source populations and thus improve statistical power....

Topics

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• Computer Simulation
• Gene Frequency
• Genetics, Population
• Genome-Wide Association Study
• Genotype
• Models, Genetic
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

73236f19-a34a-53ed-acbf-53e3fc61c744

DOI

10.1101/2021.03.09.434643