Article

Family-GWAS reveals effects of environment and mating on genetic associations

2024-10-04

Abstract excerpt

Genome-wide association studies (GWAS) have discovered thousands of replicable genetic associations, guiding drug target discovery and powering genetic prediction of human phenotypes and diseases. However, genetic associations can be affected by gene-environment correlations and non-random mating, which can lead to biased inferences in downstream analyses. Family-based GWAS (FGWAS) uses the natural experiment of r...

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Literature Corpus work: 64ff2393-6120-5727-87b0-ab104b2fe6fc
DOI: 10.1101/2024.10.01.24314703

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