Back to search

Article

Centromere landscapes resolved from hundreds of human genomes

2024-01-27

Abstract excerpt

High-fidelity (HiFi) sequencing has facilitated the assembly and analysis of the most repetitive region of the genome, the centromere. Nevertheless, our current understanding of human centromeres draws from a relatively small number of telomere-to-telomere assemblies, and so has not yet captured its full diversity. In this study, we investigated the genomic diversity of human centromere higher order repeats (HORs)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
35df5e6e-9d08-509f-a4db-94b828636213
DOI
10.1101/2024.01.26.577337
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Centromere landscapes resolved from hundreds of human genomesDOI 10.1101/2024.01.26.577337
Multidimensional variation and population stratification across 8000 complete human centromeresSemantic proximity
A global view of human centromere variation and evolutionSemantic proximity
Long-read Data Revealed Structural Diversity in Human Centromere SequencesSemantic proximity
The variation and evolution of complete human centromeresSemantic proximity
Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNASemantic proximity
HOROSCOPE: Decoding human centromere architecture from short reads using <i>k</i> -mer signaturesSemantic proximity
Complex genetic variation in nearly complete human genomesSemantic proximity
The variation and evolution of complete human centromeres.Semantic proximity
CENdetectHOR: a comprehensive tool for CENtromere profiling and HOR detectionSemantic proximity
Complete genomic and epigenetic maps of human centromeresSemantic proximity
A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese QuartetSemantic proximity
Haplotype-resolved centromeric chromatin organization from a complete diploid human genomeSemantic proximity
Select a neighboring publication to make it the new centre.