Article

Two conserved transcription factors and a histone deubiquitinase regulate the mitochondrial unfolded protein response and longevity interacting with insulin signalling.

2023-10-05

Abstract excerpt

<title>Abstract</title> Ageing is characterized by physiological decline and increased risk of agerelated diseases. The mitochondrial prohibitin (PHB) complex, a ringlike structure in the inner mitochondrial membrane, is critical to mitochondrial function and proteostasis. Depletion of PHB has opposite effects on ageing, shortening lifespan in wildtype worms while extending the lifespan of different metaboli...

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Literature Corpus work: c02feffc-45c6-5292-812e-86d1e8486054
DOI: 10.21203/rs.3.rs-3337719/v1

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Two conserved transcription factors and a histone deubiquitinase regulate the mitochondrial unfolded protein response and longevity interacting with insulin signalling.DOI 10.21203/rs.3.rs-3337719/v1Read

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