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Article

A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.

Molecular systems biology - 15 Sept 2017

Tain Luke S, Sehlke Robert, Jain Chirag, Chokkalingam Manopriya, Nagaraj Nagarjuna, Essers Paul, Rassner Mark, Grönke Sebastian, Froelich Jenny, Dieterich Christoph, Mann Matthias, Alic Nazif, Beyer Andreas, Partridge Linda

Abstract excerpt

Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long-lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, particularly in specific tissues, remain unclear. We have characterized the proteomes of four key insulin-sensitive...

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PMID: 28916541
DOI: 10.15252/msb.20177663
PMCID: PMC5615923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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