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Article

Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans.

Aging cell - 1 Feb 2014

Brejning Jeanette, Nørgaard Steffen, Schøler Lone, Morthorst Tine H, Jakobsen Helle, Lithgow Gordon J, Jensen Louise T, Olsen Anders

Abstract excerpt

NDG-4 is a predicted transmembrane acyltransferase protein that acts in the distribution of lipophilic factors. Consequently, ndg-4 mutants lay eggs with a pale appearance due to lack of yolk, and they are resistant to sterility caused by dietary supplementation with the long-chain omega-6 polyunsaturated fatty acid dihommogamma-linolenic acid (DGLA). Two other proteins, NRF-5 and NRF-6, a homolog of a mammalian...

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Identifiers

PMID: 24286221
DOI: 10.1111/acel.12165
PMCID: PMC3919970

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