Article

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes

2024-05-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. <h4>Objectives</h4> Define high-risk COPD subtypes using both genetics (polygenic risk score, PRS) and blood gene expression (transcriptional risk score, TRS) and assess differences in clinical and molecular characteristics. <h4>M...

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Literature Corpus work: bfff488e-f186-5635-953e-f29ed34bc319
DOI: 10.1101/2024.05.20.24307621

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