Article
Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine - 15 Jan 2022
Moll Matthew, Boueiz Adel, Ghosh Auyon J, Saferali Aabida, Lee Sool, Xu Zhonghui, Yun Jeong H, Hobbs Brian D, Hersh Craig P, Sin Don D, Tal-Singer Ruth, Silverman Edwin K, Cho Michael H, Castaldi Peter J
Abstract excerpt
Rationale: The ability of peripheral blood biomarkers to assess chronic obstructive pulmonary disease (COPD) risk and progression is unknown. Genetics and gene expression may capture important aspects of COPD-related biology that predict disease activity. Objectives: Develop a transcriptional risk score (TRS) for COPD and assess the contribution of the TRS and a polygenic risk score (PRS) for disease...
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