Article

Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts

2025-06-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chronic obstructive pulmonary disease (COPD) exhibits marked heterogeneity in lung function decline, mortality, exacerbations, and other disease-related outcomes. Omic risk scores (ORS) estimate the cumulative contribution of omics, such as the transcriptome, proteome, and metabolome, to a particular trait. This study evaluates the predictive value of ORS for COPD-related trai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f0e0b34-4464-5575-9ca7-f60135c46e24
DOI: 10.1101/2025.06.01.25328699

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Omic Risk Scores are Associated with COPD-related Traits Across Three CohortsDOI 10.1101/2025.06.01.25328699Read

Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributorsSemantic proximity Read

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypesSemantic proximity Read

Clustering-based COPD Subtypes Have Distinct Longitudinal Outcomes and Multi-omics BiomarkersSemantic proximity Read

Multi-omics Insights on the Disease Trajectory Linking COPD and Lung CancerSemantic proximity Read

Identifying chronic obstructive pulmonary disease subtypes using multi-trait geneticsSemantic proximity Read

Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven ModulesSemantic proximity Read

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.Semantic proximity Read

Identifying COPD subtypes using multi-trait geneticsSemantic proximity Read

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable ProteinsSemantic proximity Read

Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.Semantic proximity Read

Using omics approaches to understand pulmonary diseasesSemantic proximity Read

Multi-omics integration identifies associations between large high-density lipoprotein and lung function, asthma, and COPD: evidence from genetic and population-based analyses.Semantic proximity Read