Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.

JCI insight - 8 Apr 2026

Zhang Chengyue, Konigsberg Iain R, He Yixuan, Zhang Jingzhou, Chikowore Tinashe, Feldman William B, Hu Xiaowei, Ding Yi, Pasaniuc Bogdan, Chang Diana, Chen Qingwen, Lasky-Su Jessica A, Hecker Julian, Tobin Martin D, Chen Jing, Kalra Sean, Pratte Katherine A, Im Hae Kyung, Wan Emily S, Manichaikul Ani, Silverman Edwin K, Bowler Russell P, Lange Leslie A, Ortega Victor E, Martin Alicia R, Cho Michael H, Moll Matthew R

Abstract excerpt

BACKGROUNDWe constructed multi-trait polygenic risk scores (PRSs) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validated their performance in diverse cohorts, and identified PRS-related proteins for potential therapeutic targeting.METHODSPRSmix+, a multi-trait PRS framework, is used to train a composite PRS (PRSmulti) in COPDGene non-Hispanic White participants (n = 6,647)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Risk Score

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Proteomics

Share to Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 41712304
DOI: 10.1172/jci.insight.199951
PMCID: PMC13134720

Genes

IL1RL1
SCARF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.PMID 41712304Read ↗

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable ProteinsSemantic proximity Read ↗

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypesSemantic proximity Read ↗

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.Semantic proximity Read ↗

Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributorsSemantic proximity Read ↗

Omic Risk Scores are Associated with COPD-related Traits Across Three CohortsSemantic proximity Read ↗

Identifying chronic obstructive pulmonary disease subtypes using multi-trait geneticsSemantic proximity Read ↗

Integrative Omics Reveal Novel Protein Targets For Chronic Obstructive Pulmonary Disease Biomarker DiscoverySemantic proximity Read ↗

Identifying COPD subtypes using multi-trait geneticsSemantic proximity Read ↗

Assessing Inflammatory Protein Biomarkers in COPD Subjects with and without Alpha-1 Antitrypsin DeficiencySemantic proximity Read ↗

From early-onset asthma to chronic obstructive pulmonary disease: potential mediating proteins and therapeutic targets.Semantic proximity Read ↗

Plasma proteomic profiles predict chronic obstructive pulmonary disease up to 16 years before onset: a multi-national, machine learning-guided biomarker discovery studySemantic proximity Read ↗

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.