Article
Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.
EBioMedicine - 1 Dec 2024
Moll Matthew, Hecker Julian, Platig John, Zhang Jingzhou, Ghosh Auyon J, Pratte Katherine A, Wang Rui-Sheng, Hill Davin, Konigsberg Iain R, Chiles Joe W, Hersh Craig P, Castaldi Peter J, Glass Kimberly, Dy Jennifer G, Sin Don D, Tal-Singer Ruth, Mouded Majd, Rennard Stephen I, Anderson Gary P, Kinney Gregory L, Bowler Russell P, Curtis Jeffrey L, McDonald Merry-Lynn, Silverman Edwin K, Hobbs Brian D, Cho Michael H
Abstract excerpt
BACKGROUND: Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to define high-risk COPD subtypes using genetics (polygenic risk score, PRS) and blood gene expression (transcriptional risk score, TRS) and assess differences in clinical and molecular characteristics. METHODS: We defined high-risk groups based...
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