Article

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins

2025-08-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives.</h4> To construct multi-trait polygenic scores (PRS) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validate their performance in diverse cohorts, and identify PRS-related proteins for potential therapeutic targeting. <h4>Design</h4> Prospective cohort studies. <h4>Setting.</h4> Genetic Epidemiology of COPD (COPDGene; 2007-present), Evaluation of CO...

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Literature Corpus work: ef4927c3-3f33-58c1-933e-8ae1f3b5c394
DOI: 10.1101/2025.08.22.25334001

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