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Article

Identifying chronic obstructive pulmonary disease subtypes using multi-trait genetics

25 Feb 2025

Abstract excerpt

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) has a broad spectrum of clinical characteristics. The aetiology of these differences is not well understood. The objective of this study is to assess whether respiratory genetic variants cluster by phenotype and associate with COPD heterogeneity. METHODS: We clustered genome-wide association studies of COPD, lung function, and asthma and phenotypes from the...

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PMID: 40010152
DOI: 10.1016/j.ebiom.2025.105609

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