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Article

Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes.

International journal of chronic obstructive pulmonary disease - 1 Jan 2023

Negewo Netsanet A, Gibson Peter G, Simpson Jodie L, McDonald Vanessa M, Baines Katherine J

Abstract excerpt

Purpose: This study sought to characterize transcriptional phenotypes of COPD through unsupervised clustering of sputum gene expression profiles, and further investigate mechanisms underlying the characteristics of these clusters. Patients and methods: Induced sputum samples were collected from patients with stable COPD (n = 72) and healthy controls (n = 15). Induced sputum was collected for inflammatory cell...

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Identifiers

PMID: 36942279
DOI: 10.2147/COPD.S388297
PMCID: PMC10024507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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