Assessing Inflammatory Protein Biomarkers in COPD Subjects with and without Alpha-1 Antitrypsin Deficiency

Abstract excerpt

<h4>Rationale</h4> Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests inflammatory processes may contribute to COPD risk independently of smoking. We hypothesized that inflammatory protein biomarkers in non-AATD COPD are associated with moderate-to-severe COPD in AATD individuals, after acc...

Topics

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• alpha 1-Antitrypsin Deficiency
• Bronchoalveolar Lavage
• Exercise Tolerance
• Microbiota
• Pulmonary Emphysema
• Research Design
• Respiratory Function Tests
• Sarcoidosis

Identifiers and source

Literature Corpus work

b7bcee1f-dabb-547a-b715-088cc1c65812

DOI

10.1101/2025.01.11.25320392