Article

COATS Identifies Copy-Number-Dependent Drivers and Enablers of Aneuploidy in Cancer

2026-06-23

Abstract excerpt

Aneuploidy is a hallmark of most cancers but at the same time has been shown to decrease cellular fitness. Thus, to solve this conundrum, a current hypothesis in the field is that specific SCNAs may promote tolerance to the aneuploid state and/or promote additional chromosomal instability (CIN) and more aneuploidy. In other words, gains or losses of oncogenes (OGs) and tumor suppressor genes (TSGs) can, in turn, d...

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Literature Corpus work: baa1f2fd-1569-5ab2-8f9c-cdb5491ee321
DOI: 10.64898/2026.06.22.733880

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