Article

Cell of origin epigenetic priming determines susceptibility to <i>Tet2</i> mutation

2023-09-05

Abstract excerpt

Hematopoietic stem cell mutations can result in clonal hematopoiesis (CH) but the clinical outcomes are heterogeneous. The nature of the founder mutation and secondary mutations likely drive emergent neoplastic disease. We investigated how the state of the cell of origin where the Tet2 mutation occurs affects susceptibility to that commonly occurring CH mutation. Here, we provide evidence that risk is written in...

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Literature Corpus work: bff63c1e-54f1-5f7f-891a-e8ff6ad1c197
DOI: 10.1101/2023.09.04.556230

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