Article

<i>TET2</i> and <i>TP53</i> Mutations Cooperatively Modulate the Response to Inflammation to Promote Leukemic Transformation

2026-01-20

Abstract excerpt

TET2 is a commonly mutated gene in hematologic malignancies, including as an initiating event in clonal hematopoiesis (CH). Its mutation alters hematopoietic self-renewal, differentiation, and systemic inflammation responses. TP53 mutations co-occur with TET2 mutations and are also observed in patients with high-risk clonal hematopoiesis and hematologic malignancies. Using a murine model, we found that HSPCs wit...

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Literature Corpus work: 9c09f621-1c4c-5f99-9de5-32e48697cd02
DOI: 10.64898/2026.01.20.700390

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