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Ontogeny and Natural History of Therapy-Related Clonal Hematopoiesis From a Multidisciplinary CHIP Clinic.

American journal of hematology - 1 Aug 2026

Patel Shyam A, Zhu Valerie, Gerber William K, Suzuki Sakiko, Barker Charlotte, Hutchinson Lloyd, Khedr Salwa, Cachia David, Mangaonkar Abhishek A, McGuiness Matthew E, Higgins Anne W, Miron Patricia M, Gerber Jonathan M

Abstract excerpt

Age-related changes in human hematopoietic stem cells (HSCs) often form the basis for clonal hematopoiesis (CH), which presages the development of overt myeloid neoplasm with variable risk. CH can also arise after exposure to chemotherapy, radiotherapy, or immune interventions. In this study, we performed clinico-genomic profiling of therapy-related CH (t-CH) (n = 67) versus de novo CH (n = 123) from a...

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Identifiers

PMID: 42157378
DOI: 10.1002/ajh.70374

Genes

TET2
DNMT3A
JAK2
RUNX1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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