Article

TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling

2024-03-25

Abstract excerpt

<title>Abstract</title> <p>Ten-Eleven Translocation-2 (<italic>TET2</italic>) mutations drive the expansion of mutant hematopoietic stem cells (HSCs) in clonal hematopoiesis (CH). However, the precise mechanisms by which <italic>TET2</italic> mutations confer a competitive advantage to HSCs remain unclear. Here, through an epigenetic drug screen, we discovered that inhibition of disruptor of telomeric silencing 1...

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Literature Corpus work: c1eefe72-2195-5001-9d63-e1999c64adde
DOI: 10.21203/rs.3.rs-4151500/v1

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