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Article

60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.

Experimental hematology - 1 Mar 2020

Ayachi Sami, Buscarlet Manuel, Busque Lambert

Abstract excerpt

The history of clonal hematopoiesis (CH) research is punctuated by several seminal discoveries that have forged our understanding of cancer development. The clever application of the principle of random X-chromosome inactivation (XCI) in females led to the development of the first test to identify clonal derivation of cells. Initially limited by a low level of informativeness, the applicability of these assays...

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PMID: 32001340
DOI: 10.1016/j.exphem.2020.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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