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Article

Cell of origin epigenetic priming determines susceptibility to Tet2 mutation.

Nature communications - 21 May 2024

Schiroli Giulia, Kartha Vinay, Duarte Fabiana M, Kristiansen Trine A, Mayerhofer Christina, Shrestha Rojesh, Earl Andrew, Hu Yan, Tay Tristan, Rhee Catherine, Buenrostro Jason D, Scadden David T

Abstract excerpt

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors, we find that the epigenetic features of clones at similar differentiation status are highly heterogeneous and functionally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38773071
DOI: 10.1038/s41467-024-48508-6
PMCID: PMC11109152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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