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Article

TET2 mutation as prototypic clonal hematopoiesis lesion.

Seminars in hematology - 1 Feb 2024

Guarnera Luca, Jha Babal K

Abstract excerpt

Loss of function TET2 mutation (TET2MT) is one of the most frequently observed lesions in clonal hematopoiesis (CH). TET2 a member TET-dioxygenase family of enzymes that along with TET1 and TET3, progressively oxidize 5-methyl cytosine (mC) resulting in regulated demethylation of promoter, enhancer and silencer elements of the genome. This process is critical for efficient transcription that determine cell...

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Source

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Identifiers

PMID: 38431463
DOI: 10.1053/j.seminhematol.2024.01.013
PMCID: PMC10978279

Genes

TET2
TET1
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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