Article

<i>Id1</i> Promotes Clonal Hematopoiesis in Mice with <i>Tet2</i> Loss of Function

2024-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Hematopoietic malignancies emerge through the gradual acquisition of genetic mutations within hematopoietic stem and progenitor cells (HSPCs). Mutations that occur early in disease progression impart a selective growth advantage to HSPCs, which allows them to expand and contribute to a substantial percentage of mature blood cells. This increased expansion is termed clonal hematopoiesis (CH) and...

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Literature Corpus work: 26ee1fa9-ab0a-5b2c-8ec9-1b8f39f2b44b
DOI: 10.1101/2024.11.19.624318

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