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Article

Molecular mechanisms of KMT2C alterations in gastrointestinal cancers: enhancer network destabilization, lineage plasticity, and clinical translation.

Frontiers in immunology - 1 Jan 2026

Zeng Xintao, Yang Pei, Wang Tao, Shi Ruizi, Qin Chuan, Zhang Lun, Jiang Ting, Chen Xi, Luo Hua, Wei Jihong, Hu Haiyan, Wang Decai, Wang Jianjun

Abstract excerpt

KMT2C (lysine methyltransferase 2C), also known as mixed-lineage leukemia 3 (MLL3), is a member of the KMT2 family of histone methyltransferases that catalyzes histone H3 lysine 4 monomethylation (H3K4me1), a hallmark of active enhancer elements. Operating within COMPASS-like complexes (Complex of Proteins Associated with Set1) and in association with the ASCOM coactivator complex (ASC-2-containing complex),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42292428
DOI: 10.3389/fimmu.2026.1799765
PMCID: PMC13254021

Genes

KMT2C
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Molecular mechanisms of KMT2C alterations in gastrointestinal cancers: enhancer network destabilization, lineage plasticity, and clinical translation.PMID 42292428Read ↗

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