Article

EZH1-dependent H3K27me1 is an adaptive chromatin barrier that limits DNMT inhibitor response in colorectal cancer

2025-09-18

Abstract excerpt

Abnormal DNA methylation patterning is a defining epigenetic hallmark of human cancer and is therapeutically targetable with DNA methyltransferase inhibitors (DNMTi’s). However, DNMTi-induced DNA hypomethylation promotes adaptive chromatin remodeling that limits molecular and therapeutic responses to these drugs. Here, we identify EZH1-dependent H3K27 mono-methylation (H3K27me1) as a previously unrecognized adapti...

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Literature Corpus work: 5dfca352-4b0c-554b-a69a-0acd3a93ff79
DOI: 10.1101/2025.09.16.676613

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