Article

<i>MLL4/KMT2D</i> mutations increase immune activity and predict therapy efficacy in colorectal cancer

2026-08-03

Abstract excerpt

<h4>Background</h4> The KMT2D histone 3-lysine 4 methyltransferase (also known as MLL4) is a critical chromatin regulator, which is frequently inactivated by gene mutations in various types of cancer including colorectal cancer (CRC). Several lines of evidence suggest a strong association between chromatin regulation, tumor immunity and drug sensitivity. To explore the role of KMT2D in tumor immunity, we analyz...

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Literature Corpus work: 5a006fb8-6710-58be-99d3-7ad9e74560fe
DOI: 10.64898/2026.07.31.742076

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