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Article

NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression

11 Mar 2019

Abstract excerpt

N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation of histone H4 (N-acH4) to colorectal cancer (CRC). However, the role of NAA40 in CRC development was not investigated. Here, we show that NAA40 protein and mRNA levels are commonly increased...

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PMID: 30858358
DOI: 10.1038/s41419-019-1487-3

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