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Article

Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression.

Clinical epigenetics - 29 May 2020

Larsson Chatarina, Cordeddu Lina, Siggens Lee, Pandzic Tatjana, Kundu Snehangshu, He Liqun, Ali Muhammad Akhtar, Pristovšek Nuša, Hartman Karin, Ekwall Karl, Sjöblom Tobias

Abstract excerpt

BACKGROUND: The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequently recurring mutation in colorectal cancer (CRC) with microsatellite instability is a single nucleotide deletion within the exon 38 poly-A(9) repeat (c.8390delA) which results in frameshift...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32471474
DOI: 10.1186/s13148-020-00863-z
PMCID: PMC7257146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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