Article

Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation

2024-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated epigenetic programs that restrict differentiation, reactivate fetal genes, and confer phenotypic plasticity are critical to colorectal cancer (CRC) development. By screening a small molecule library targeting epigenetic regulators using our dual reporter system, we found that inhibiting histone deacetylase (HDAC) 1/2 promotes CRC differentiation and anti-tumor activity. Comprehensiv...

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Literature Corpus work: 601cd99f-ed4f-5824-8ab5-bdd7ddcb0086
DOI: 10.1101/2024.12.06.626451

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