Article

Chromatin Bridges, not Micronuclei, Activate cGAS after Drug-induced Mitotic Errors in Human Cells

2021-02-02

Abstract excerpt

<h4>Summary</h4> Mitotic errors can activate cGAS and induce type-I interferon (IFN) signaling. Current models propose that chromosome segregation errors generate micronuclei whose rupture activates cGAS. We used a panel of anti-mitotic drugs to perturb mitosis in fibroblasts and measured abnormal nuclear morphologies, cGAS localization and IFN signaling in the subsequent interphase. Micronuclei consistently recr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0630e204-a549-5b3b-9301-28c52b0c0114
DOI: 10.1101/2021.02.02.429360

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromatin Bridges, not Micronuclei, Activate cGAS after Drug-induced Mitotic Errors in Human CellsDOI 10.1101/2021.02.02.429360Read

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errorsSemantic proximity Read

Cell confinement initiates a delayed but heritable loss of chromosomesSemantic proximity Read

Profiling DNA damage response following mitotic perturbations.Semantic proximity Read

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cellsSemantic proximity Read

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errorsSemantic proximity Read

Epigenetic dysregulation from chromosomal transit in micronucleiSemantic proximity Read

Nuclear envelope assembly defects link mitotic errors to chromothripsisSemantic proximity Read

Human Cancer Cells Commonly Acquire DNA Damage during Mitotic ArrestSemantic proximity Read

DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failuresSemantic proximity Read

Pauperization of Emerin from nuclear envelope during chromatin bridge resolution drives prostate cancer cell migration and invasivenessSemantic proximity Read

Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STINGSemantic proximity Read

Mitotic chromatin marking governs asymmetric segregation of DNA damageSemantic proximity Read