Article
Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.
Scientific reports - 20 Feb 2020
Evans Simon L, Dowell Nicholas G, Prowse Fenella, Tabet Naji, King Sarah L, Rusted Jennifer M
Abstract excerpt
Carriers of the APOE e4 allele are at higher risk of age-related cognitive decline and Alzheimer's disease (AD). The underlying neural mechanisms are uncertain, but genotype differences in medial temporal lobe (MTL) functional activity and structure at mid-age might contribute. We tested 16 non-e4 and 16 e4 carriers (aged 45-55) on a subsequent memory task in conjunction with MRI to assess how hippocampal volume...
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