Article

Parkinsonism originates in a discrete secondary and dystonia in a primary motor cortical-basal ganglia subcircuit

2022-08-26

Abstract excerpt

Although manifesting contrasting phenotypes, Parkinson’s disease and dystonia originate from similar pathophysiology. Previously, we lesioned a discrete dorsal region in the globus pallidus (rodent equivalent to globus pallidus externa) in rats and produced parkinsonism, while lesioning a nearby ventral hotspot induced dystonia. Presently, we injected anterograde fluorescent-tagged anterograde multi-synaptic trace...

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Literature Corpus work: 564e39ba-2e50-5275-88d9-4880ba998a1e
DOI: 10.21203/rs.3.rs-1953051/v1

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