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Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin Mutation

2022-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Impaired executive function is a common and debilitating non-motor symptom of idiopathic and hereditary Parkinson’s disease (PD), but there is little understanding of the underlying pathophysiological mechanisms and circuits. The G2019S mutation in the kinase domain of leucine-rich repeat kinase 2 ( LRRK2 ) greatly increases risk for late-onset PD, and non-manifesting LRRK2 -G2019S carriers al...

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Literature Corpus work
3281cdb3-94e1-5082-8def-9e313c1d52b8
DOI
10.1101/2022.01.26.477929
Open publication

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Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson’s Disease LRRK2-G2019S Knockin MutationDOI 10.1101/2022.01.26.477929
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