Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration

2 Jul 2021

Abstract excerpt

A deeper understanding of early disease mechanisms occurring in Parkinson's disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons (DAn) obtained from healthy individuals or patients harboring LRRK2 PD-causing mutation can create highly complex networks with evident signs of functional maturation over time. Compared to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Neurological disorders and treatments
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34215735
DOI: 10.1038/s41531-021-00198-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegenerationPMID 34215735Read ↗

Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson’s DiseaseSemantic proximity Read ↗

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s diseaseSemantic proximity Read ↗

Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S MutationSemantic proximity Read ↗

The pathology roadmap in Parkinson diseaseSemantic proximity Read ↗

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's diseaseSemantic proximity Read ↗

Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S MutationSemantic proximity Read ↗

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and FunctionalitySemantic proximity Read ↗

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity Read ↗

Parkinson's disease in a dish - Using stem cells as a molecular tool.Semantic proximity Read ↗

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode ArraysSemantic proximity Read ↗

iPSC-derived extracellular vesicles rescue deficits in human and mouse models of Parkinson’s diseaseSemantic proximity Read ↗

Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.