Article
Anatomical and functional analysis of the corticospinal tract in an FRDA mouse model
2024-07-02
Abstract excerpt
Friedreich’s ataxia (FRDA) is one of the most common hereditary ataxias. It is caused by a GAA repeat in the first intron of the FXN gene, which encodes an essential mitochondrial protein. Patients suffer from progressive motor dysfunction due to the degeneration of mechanoreceptive and proprioceptive neurons in dorsal root ganglia (DRG) and cerebellar dentate nucleus neurons, especially at early disease stages. P...
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Identifiers and source
- Literature Corpus work
- 6b87e048-f68d-5eab-ba4a-a9f3f6e07363
- DOI
- 10.1101/2024.06.28.601178