Article

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations

2020-05-23

Abstract excerpt

The ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by the α-ketoglutarate-dependent dioxygenase, AlkBH3. Other ASCC components integrate ASCC3/AlkBH3 into a complex DNA repair pathway. We mapped and structurally analyzed interacting ASCC2 and ASCC3 regions. The ASCC3 fragment comprises a...

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Identifiers and source

Literature Corpus work: b050b037-9667-5310-af85-d8d61d3640f4
DOI: 10.1101/2020.05.22.111591

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