Article
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Molecular cell - 4 Nov 2011
Dango Sebastian, Mosammaparast Nima, Sowa Mathew E, Xiong Li-Jun, Wu Feizhen, Park Keyjung, Rubin Mark, Gygi Steve, Harper J Wade, Shi Yang
Abstract excerpt
Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little is known about their functions in mammalian cells. We report the purification of the ALKBH3 complex and demonstrate its association with the activating signal cointegrator complex (ASCC). ALKBH3 is overexpressed in various cancers, and both ALKBH3 and ASCC are important for alkylation...
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