Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.

Nature communications - 2 Nov 2020

Jia Junqiao, Absmeier Eva, Holton Nicole, Pietrzyk-Brzezinska Agnieszka J, Hackert Philipp, Bohnsack Katherine E, Bohnsack Markus T, Wahl Markus C

Abstract excerpt

The ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by the α-ketoglutarate-dependent dioxygenase AlkBH3. Other ASCC components integrate ASCC3/AlkBH3 into a complex DNA repair pathway. We mapped and structurally analyzed interacting ASCC2 and ASCC3 regions. The ASCC3 fragment comprises a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Protein Conformation, alpha-Helical

Share to Protein Domains

Share to Ribonucleoproteins, Small Nuclear

Share to RNA Helicases

Share to Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 33139697
DOI: 10.1038/s41467-020-19221-x
PMCID: PMC7608686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.PMID 33139697Read ↗

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutationsSemantic proximity Read ↗

DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.Semantic proximity Read ↗

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responsesSemantic proximity Read ↗

The Link Between Human Alkyladenine DNA Glycosylase and Cancer DevelopmentSemantic proximity Read ↗

Hemizygous loss of helicases promotes genomic instability and cancer development.Semantic proximity Read ↗

Ubiquitin E3 ligases in cancer: somatic mutation and amplificationSemantic proximity Read ↗

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.Semantic proximity Read ↗

Loss of HMCES is synthetic lethal with APOBEC activity in cancer cellsSemantic proximity Read ↗

The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer.Semantic proximity Read ↗

Functional defects of cancer-associated MDC1 mutations in DNA damage repair.Semantic proximity Read ↗

KDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damageSemantic proximity Read ↗

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSαSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.