Article

Germline regulation of tumor evolutionary dynamics shapes multiple myeloma progression

2026-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Germline variation shapes cancer risk, yet its influence on the evolutionary dynamics of established tumors remains poorly understood. In multiple myeloma, subclonal diversification drives disease progression and treatment failure, but the heritable factors that modulate this process are unknown. Here, we show that germline variation is associated with tumor evolutionary features, implicating in...

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Literature Corpus work: bec1f855-d110-536a-8949-4038da82ac45
DOI: 10.64898/2026.06.05.730550

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