Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.

doi:10.1038/ncomms3997

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Article

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.

Nature communications - 1 Jan 2014

Bolli Niccolo, Avet-Loiseau Hervé, Wedge David C, Van Loo Peter, Alexandrov Ludmil B, Martincorena Inigo, Dawson Kevin J, Iorio Francesco, Nik-Zainal Serena, Bignell Graham R, Hinton Jonathan W, Li Yilong, Tubio Jose M C, McLaren Stuart, O' Meara Sarah, Butler Adam P, Teague Jon W, Mudie Laura, Anderson Elizabeth, Rashid Naim, Tai Yu-Tzu, Shammas Masood A, Sperling Adam S, Fulciniti Mariateresa, Richardson Paul G, Parmigiani Giovanni, Magrangeas Florence, Minvielle Stephane, Moreau Philippe, Attal Michel, Facon Thierry, Futreal P Andrew, Anderson Kenneth C, Campbell Peter J, Munshi Nikhil C

Abstract excerpt

Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma samples. Most cases have a complex subclonal structure and show clusters of subclonal variants, including subclonal driver mutations. Serial sampling reveals diverse patterns of clonal evolution,...

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PMID: 24429703
DOI: 10.1038/ncomms3997
PMCID: PMC3905727

Genes

EGR1
LTB
ROBO1

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