Article
Designing Evolutionary-based Interception Strategies to Block the Transition from Precursor Phases to Multiple Myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2021
Maura Francesco, Landgren Ola, Morgan Gareth J
Abstract excerpt
The development of next-generation sequencing technology has dramatically improved our understanding of the genetic landscape of multiple myeloma. Several new drivers and recurrent events have been reported and linked to a potential driver role. This complex landscape is enhanced by intraclonal mutational heterogeneity and variability introduced through the dimensions of time and space. The evolutionary history...
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