Evolution of multiple myeloma from a genomic perspective.

doi:10.1182/blood.2024026313

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Article

Evolution of multiple myeloma from a genomic perspective.

Blood - 26 Mar 2026

Maura Francesco, Samur Mehmet, Munshi Nikhil

Abstract excerpt

ABSTRACT: In this review, we explore the role of complex interactions between genomic evolution, environmental and genetic predispositions, and immune surveillance in disease progression from precursor conditions smoldering multiple myeloma and monoclonal gammopathy of undetermined significance to multiple myeloma (MM). MM has been described to be universally preceded by precursor states, often decades before it...

Topics

Humans
Multiple Myeloma
Genomics
Genetic Predisposition to Disease
Disease Progression
Evolution, Molecular

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Identifiers

PMID: 41359792
DOI: 10.1182/blood.2024026313
PMCID: PMC13077438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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