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Article

Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma.

Leukemia - 1 Aug 2014

Melchor L, Brioli A, Wardell C P, Murison A, Potter N E, Kaiser M F, Fryer R A, Johnson D C, Begum D B, Hulkki Wilson S, Vijayaraghavan G, Titley I, Cavo M, Davies F E, Walker B A, Morgan G J

Abstract excerpt

Although intratumor heterogeneity has been inferred in multiple myeloma (MM), little is known about its subclonal phylogeny. To describe such phylogenetic trees in a series of patients with MM, we perform whole-exome sequencing and single-cell genetic analysis. Our results demonstrate that at presentation myeloma is composed of two to six different major clones, which are related by linear and branching...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24480973
DOI: 10.1038/leu.2014.13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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